Arendelia Pharmaceuticals faces slowing organic growth as its Frozen Heart Syndrome patient market approaches saturation at 90% eligibility. The case challenges candidates to determine current growth sustainability and recommend optimal allocation of a $15B investment budget across six new disease area products. The solution involves selecting Products A, C, and D based on expected value calculations while acknowledging execution risks.
Key Insights:
- Recognize market saturation: 90% patient eligibility signals plateau in FHS growth despite high historical revenue increases
- Apply expected value formula: EV = (Revenue - Costs) × Probability of Success + (Failure costs) × (1 - Probability), accounting for phase-likelihood correlation
- Understand budget constraints: All selected products must total ≤$15B with acquisition costs included in budget but excluded from EV calculations (sunk cost concept)
- Balance portfolio risk: Select Product D (higher phase/approval likelihood) over Product B (identical financials but earlier stage) and diversify across multiple products rather than concentration
- Risk mitigation: Address execution risks (FDA approval, acquisition integration, supply chain) and non-financial considerations (patient perception, internal resource capacity)