Chicken Pox Vaccine

ProHub Comment

This is a quantitatively heavy investment decision case requiring the candidate to build a market sizing model, apply pricing insights from demand curves, and calculate profitability metrics. The key analytical insight is recognizing that post-saturation, revenues drop to replacement demand (new births), creating a finite high-value market window. The case tests whether candidates can identify the addressable market using the infection rate distribution curve and translate that into a breakeven and NPV analysis.

Estimated Time 15 minutes
Difficulty Medium
Source Chicago Booth
50 / 100

Your client is a large pharmaceutical drug company working on a vaccine for chicken pox. The vaccine needs to pass three phases of testing to be approved by the FDA. It has just completed the second phase, and the client is asking for your help to decide if they should fund the third phase. The third phase would last 2 years and cost $300M. Results from previous phases indicate the vaccine has a 95% chance of approval. We would be able to start producing vaccine immediately following approval.

Should our client invest or not?

Clarifying Information

  1. Vaccine is a one time injection.
  2. Assume US population is 300M, and it is uniformly distributed from 0-75 (as many people enter population as leave every year).
  3. It is estimated that it would take 3 years to vaccinate existing population, and would be done at an even pace.
  4. Costs (per injection): Distribution $1.50, Production $2.50, SG&A $5.00
  5. Assume the $300M costs for phase three includes everything else (plant set up costs, etc.) and can be expensed evenly over the 2 years of testing.
  6. Vaccine will not be patented.
  7. Other companies would have to undergo same series of testing and no other companies have started formal testing of vaccine.
  8. Phase 1 and 2 combined take 3 years (we have 3 years of competitive protection); Phase 1 and 2 cost $200M.